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Quantitative Life Sciences

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Thermodynamic signatures of sensing and amplification by periodically-driven hair-cell bundles

By operating in different thermodynamics modes, hair cell bundles in the inner ear dynamically regulate power exchange with mechanical signals at the smallest biological scales.

Post Publication

Microcanonical ensemble out of equilibrium

How to drive a microcanonical ensemble out of equilibrium? While statistical mechanics explains macroscopic physical laws from the atomistic point of view, nonequilibrium thermodynamics has largely remained a phenomenological discipline. Here we extend the microcanonical method beyond equilibrium.

Post Publication

Minecraft-ing our way into studying cell sorting

A new framework reveals the role of dissipative timescales and nonequilibrium thermodynamics in shaping complex biological structures. The collective properties of active systems depend not only on the accessible energy states, but also on the transient dynamics. A new framework for dynamical discrete-state systems—a Poissonian extension of the Cellular Potts model widely used in cancer research and development biology–now permits studying thermodynamic and kinetic aspects of biological tissues.

Post Publication

EPI/PrE sorting in mouse blastocyst

Excited to present soon in Trieste our novel approach to cellular Potts models

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(Post)modern thermodynamics | Luxembourg

Fabulous winter lights in Luxembourg and (Post)modern thermodynamics—a school and workshop with a philosophical twist, in which I had the honor to give a short talk.

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