Poissonian Cellular Potts Models Reveal Nonequilibrium Kinetics of Cell Sorting

R. Belousov (@ribelousov), S. Savino, P. Moghe (@MoghePrachiti), T. Hiiragi, L. Rondoni, and A. Erzberger (@ErzbergerGroup) | Open Access by CC BY 4.0

Our recent PRL publication, which describes a new framework revealing the role of dissipative timescales and nonequilibrium thermodynamics in shaping complex biological structures, has been spotlighted in EMBL Communications! The collective properties of active systems depend not only on the accessible energy states, but also on the transient dynamics. A new framework for dynamical discrete-state systems–a Poissonian extension of the Cellular Potts model widely used in cancer research and development biology–now permits studying thermodynamic and kinetic aspects of biological tissues.

https://doi.org/10.1103/PhysRevLett.132.248401

R. Belousov¹, S. Savino^{1, 2}, P. Moghe^{1, 3}, T. Hiiragi^{1, 3}, L. Rondoni², A. Erzberger¹.

¹ EMBL—European Molecular Biology Laboratory, Meyerhofstraße 1, 69117 Heidelberg, Germany; ² PoliTo—Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy; ³ Hubrecht institute, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.

Poissonian cellular Potts models come to Leiden!

Excited to present soon in Trieste our novel approach to cellular Potts models—a result of a very fruitful collaboration between @ErzbergerGroup and Hiiragi lab on a project developed by @PrachitiMoghe!

Fabulous winter lights in Luxembourg and (Post)modern thermodynamics—a school and workshop with a philosophical twist, in which I had the honor to give a short talk.

Frenesy-entropy decomposition in “action”

R. Belousov¹, S. Savino^{1, 2}, P. Moghe^{1, 3}, T. Hiiragi^{1, 3}, L. Rondoni², A. Erzberger¹.

¹ EMBL—European Molecular Biology Laboratory, Meyerhofstraße 1, 69117 Heidelberg, Germany; ² PoliTo—Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy; ³ Hubrecht institute, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.

The Ito-Stratonovich dilemma has been solved: again 😅, but this time together with the Smoluchowski–Fokker-Planck dilemma for inhomogeneous diffusion—most definitely 🧐!
Phys. Rev. E 106, 2022.

Statistical physics of inhomogeneous transport: Unification of diffusion laws and inference from first-passage statistics

• @ribelousov
• Ali Hassanali
• @edgarroldankb

I had the honor of being an invited speaker at the Physics of Life 2022 summer school in Edingburgh. Unfortunately, due to the COVID-19, my contribution turned into an online talk…

Energetics of cellular and multicellular organization

Our humble contribution to the fight with COVID-19 pandemic is out in the OPEN ACCESS: EPJE 44 (11), 2021.

Phospholipids dock SARS-CoV-2 spike protein via hydrophobic interactions: a minimal in-silico study of lecithin nasal spray therapy

• @ribelousov
• in touch with @edgarroldankb’s lab, @ictpnews.