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Quantitative Life Sciences

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Physics is not Mathematics

Can a mathematically rigorous model still be physically irrelevant? Absolutely. That observation may lie at the heart of physics. Here is an example for my colleagues from biology: You can classify a dragon, model its fire-breathing mathematically, and still fail to conjure biology...

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Thermodynamic signatures of sensing and amplification by periodically-driven hair-cell bundles

By operating in different thermodynamics modes, hair cell bundles in the inner ear dynamically regulate power exchange with mechanical signals at the smallest biological scales.

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Microcanonical ensemble out of equilibrium

How to drive a microcanonical ensemble out of equilibrium? While statistical mechanics explains macroscopic physical laws from the atomistic point of view, nonequilibrium thermodynamics has largely remained a phenomenological discipline. Here we extend the microcanonical method beyond equilibrium.

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Minecraft-ing our way into studying cell sorting

A new framework reveals the role of dissipative timescales and nonequilibrium thermodynamics in shaping complex biological structures. The collective properties of active systems depend not only on the accessible energy states, but also on the transient dynamics. A new framework for dynamical discrete-state systems—a Poissonian extension of the Cellular Potts model widely used in cancer research and development biology–now permits studying thermodynamic and kinetic aspects of biological tissues.

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EPI/PrE sorting in mouse blastocyst

Excited to present soon in Trieste our novel approach to cellular Potts models

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